However, most of these delivery approaches are not optimized to enable the intracellular trafficking of the siRNAs into the cytoplasm where they must associate with the RNA-induced silencing complex (RISC) to direct the cleavage of mRNAs bearing complementary binding sites. Recent studies have shown significant progress in the development of targeting reagents that facilitate the recognition of and siRNA delivery to specific cell types. The application of small interfering (si)RNAs as potential therapeutic agents requires safe and effective methods for their delivery to the cytoplasm of the target cells and tissues. RNA interference (RNAi)-based technologies offer an attractive strategy for the sequence-specific silencing of disease-causing genes.
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Main Headings of Article Following main headings should be provided in the article while preparing.Table made with the open model ( without the vertical lines) The citation quick guide can be found at Chicago Manual of Style 17 th edition (full note)įigures and Tables The figures should be readable and at least have a resolution of 300 DPI (Dots Per Inch) for good printing quality. The reference list must be 80% of national and international journals, thesis, dissertation, and proceedings 20% of Bibliographies come from books or anything else except Wikipedia and personal blogs. The way of writing references is first categorized and then sorted alphabetically by the author. References that can be referred to are all publications in the last 10 (ten) years, except for unique references that have never been reissued. Use other published articles in the same journal as models. 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